Herpes simplex virus type 1 (HSV-1) is commonly encountered first during childhood as an oral infection. Intra-visual cortex inoculation of 10(2) plaque-forming units of herpes simplex virus type 1 (KOS-63) induced physiologic and morphologic retinal changes in 62.3% (33/53) of infected animals; of these, 91% were bilateral. Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. By ultracentrifugation of 30 ml of highly dilute suspensions of herpes simplex virus (HSV) directly onto monolayer cultures grown in centrifuge tubes, infectivity was significantly greater than without centrifugation. Auto-inoculation from a genital ulcer suspected of being ulcus molle gave redness after 24 hours and after 48 hours vesicles and pustules appeared. This study aimed to establish the influence of herpes simplex virus (HSV) on testis morphology and germ cell development using a model of ascending urogenital HSV infection in mice. Isolation of herpes simplex virus and production of CF antigen was tried in chorioallantoic membranes of embryonated duck eggs.
Ultracentrifugation of very dilute suspensions of herpes simplex virus directly onto monolayer cells grown in centrifuge tubes was studied. This article has been cited by other articles in PMC. The herpes simplex virus (HSV) has the ability to replicate in the central nervous system (CNS), which may cause fatal encephalitis. Multiple entry receptors can mediate infection of cells by herpes simplex virus (HSV), permitting alternative pathways for infection and disease. BACKGROUND: After placement of herpes simplex virus type 1 (HSV-1) into the esophageal lumen of BALB/c mice, the virus replicated in enteric neurons within the esophagus and stomach and was transported to the sensory ganglia of the vagus nerve (nodose ganglia), where viral replication also occurs and where ultimately a long term latent infection is established. PNAS is the world’s most-cited multidisciplinary scientific serial. This article has been cited by other articles in PMC.
Following anterior chamber inoculation of herpes simplex virus type 1 (HSV-1) into one eye of adult, immunocompetent BALB/c mice, an interesting pattern of ocular pathology and systemic immune responses emerges, characterized by destruction of the contralateral retina with sparing of the ipsilateral retina; and impairment of delayed hypersensitivity (DH) accompanied by intact humoral immunity to the virus. An animal model of vestibular neuritis was developed by inoculating herpes simplex virus type 1 (HSV—1) in the auricle of a mouse. It has been shown that injection of herpes simplex virus type 1 into the vitreous body of the eye in 18-day-old albino rabbits consistently induced encephalitis caused by herpes simplex virus, with 95% survival. Adult male Syrian hamsters were inoculated subcutaneously with herpes simplex virus type 1 (HSV-1, 10(6) PFU) or ultraviolet-inactivated HSV-1. Herpes simplex virus Type 1 (HSV-1) inoculated intracamerally (IC) into the anterior chamber of BALB/c eyes induces anterior chamber associated immune deviation (ACAID) in which T cell-mediated delayed type hypersensitivity (DTK) responses to HSV-1 are impaired while B cell-mediated anti-HSV neutralizing antibody responses are intact or enhanced. This article has been cited by other articles in PMC. Description: Founded in 1904, The Journal of Infectious Diseases is the premier publication in the Western Hemisphere for original research on the pathogenesis, diagnosis, and treatment of infectious diseases, on the microbes that cause them, and on disorders of host immune mechanisms.
Vidal, 1873, first demonstrated the Herpes Simplex Virus to be infections caused by human inoculation (8). A DNA hybridization technique, using the polyrepetitiveEcoRI L-fragment of bovid herpesvirus (BHV-4) as a probe, was developed to determine virus distribution in the tissues of BHV-4-infected pregnant rabbits. Infection of trigeminal ganglion by herpes simplex virus (HSV) thymidine kinase-negative (TK-) mutants was investigated in mixed infection studies in mice. Ten cows (5 pregnant and 5 non pregnant) were inoculated with a BHV 4 (Bovine Herpes Virus 4) strain LVR 140.